Alligator-Derived Hyaluronic Acid: Bacteriostatic and Fungastatic Properties Against Pathogens
Non-healing wounds are often stalled in the inflammatory phase and considered hard-to-heal or chronic wounds when healing is delayed for over 4 weeks, and up to more than three months. The longer it takes these wounds to heal poses a severe risk for a polymicrobial infection which can stall the wound even further in the inflammatory phase and is concomitant with a higher incidence of lower extremity amputation and mortality.
Hyaluronic acid has been utilized in wound care to replenish and stabilize the extracellular matrix in a chronic wound bed. Hyaluronic acid has also been shown to protect stem cells, growth factors, and cytokines required for cell proliferation and angiogenesis. Considering that alligator tissues have been found to have bacteriostatic and fungistatic properties, it is possible that alligator-derived hyaluronic acid may play a critical role in reducing the bioburden to promote chronic wound healing.
In the paper “Alligator-Derived Hyaluronic Acid: Bacteriostatic and Fungastatic Properties Against Pathogens” published in Wound Masterclass journal, our Product Development Laboratory team worked with Dr. Swathi Balaji of Texas Children’s Hospital, Dr. Thomas Serena of SerenaGroup, and Ted Bundrick of Lacerta Life Sciences, to provide evidence that alligator-derived hyaluronic acid can act on the inflammatory phase of wound healing.
The list of Alira Health’s contributors include:
- Mitch Sanders, PhD, Chief Scientific Officer
- Mia Hanna, Research Associate III, Project Manager
- Vanessa Vu, Research Associate I
- Lindsay Poland, Scientist III, Lab Operations Mgr.
The paper “Alligator-Derived Hyaluronic Acid: Bacteriostatic and Fungastatic Properties Against Pathogens” is available on page 60 of Volume 1: Issue 3 (December 2022) of Wound Masterclass.